Quinto makes it easy to manage permissions. You can assign permission sets in bulk from the users table.
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Click the gear icon on the top right of your screen.
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Select User management in the dropdown.
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Search for and select the user in the table.
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Click Assign in the menu at the top of the table.
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Select Assign permission sets in the drop-down.
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Select the permission sets you want to assign (you can add multiple).
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Select the checkbox to remove the other permission sets assigned to these users.
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Click Assign to confirm.